March 1, 1996Hypertension

SA Gene Expression in the Proximal Tubule of Normotensive and Hypertensive Rats

View Full Paper

Ask AI

Bookmark

Population

Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHRs), and Wistar-Kyoto (WKY) rats

Comparison

Genetic hypertension or induced hypertension vs Normotensive controls (SD and WKY rats)

Design

Preclinical

Authors

TYTianxin YangUniversity of Utah SHSohail HassanLincoln University College ISInderjit SinghUniversity of the Potomac

Discussion

Member takes

Implication

Remains preclinical; leaves open whether SA gene patterns contribute to hypertension or guide therapies in humans.

Structured PICO

Population

Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHRs), and Wistar-Kyoto (WKY) rats

Intervention

Genetic hypertension (SHRs) or induced hypertension (two-kidney, one-clamp Goldblatt model in SD rats)

Comparator

Normotensive controls (SD and WKY rats)

Outcome

Localization and expression pattern of SA gene mRNA in kidney nephron segments measured by semiquantitative RT-PCRsurrogate

Spontaneous hypertension in rats is associated with an extended pattern of SA gene expression along the entire proximal tubule compared to normotensive strains.

Cite This Study

Yang et al. (1996) studied this question.

synapsesocial.com/papers/6a8be42e71fd1aba2c8b9567 https://doi.org/10.1161/01.hyp.27.3.541

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

SA Gene Expression in the Proximal Tubule of Normotensive and Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

SA Gene Expression in the Proximal Tubule of Normotensive and Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider