Population
Male F2 rats bred from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Inheriting two SHR alleles of the SA gene vs Inheriting two WKY alleles of the SA gene
Design
Preclinical
Authors
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No immediate clinical implications; leaves open SA gene relevance to human hypertension.
The SA gene, or a closely linked gene, influences blood pressure in a rat model of spontaneous hypertension.
Iwai et al. (1992) studied this question.
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