August 1, 2001Hypertension

Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1

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Population

Spontaneously hypertensive rats, Wistar-Kyoto rats, and derived congenic substrains

Comparison

Introgressed genetic segments around the Sa gene… vs Respective parental strains (WKY and SHR)

Design

Preclinical

Authors

SFSimon FrantzUniversity of Würzburg JCJenny-Rebecca ClemitsonGlenfield Hospital MBMarie‐Thérèse BihoreauCommissariat à l'Énergie Atomique et aux Énergies Alternatives

Discussion

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Implication

At least two BP QTLs on rat chromosome 1 act independently of Sa; hypothesis-generating for hypertension genetics, with no clinical implications yet.

Structured PICO

Population

Spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), and derived congenic substrains (WISA1, WISA2, SISA1, SISA2)

Intervention

Introgressed genetic segments around the Sa gene on rat chromosome 1

Comparator

Respective parental strains (WKY and SHR)

Outcome

Blood pressure differencesurrogate

The study identifies at least two quantitative trait loci affecting blood pressure on rat chromosome 1, demonstrating that the blood pressure effect in this region is not solely due to the Sa gene.

Cite This Study

Frantz et al. (2001) studied this question.

synapsesocial.com/papers/6a880170a95381ace1bbf212 https://doi.org/10.1161/01.hyp.38.2.216

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

At least two BP QTLs on rat chromosome 1 act independently of Sa; hypothesis-generating for hypertension genetics, with no clinical implications yet.

Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Genetic Dissection of Region Around the Sa Gene on Rat Chromosome 1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider