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September 12, 1995Proceedings of the National Academy of SciencesOpen Access

Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

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Population

Rat models including stroke-prone spontaneously hypertensive rat, normotensive Wistar-Kyoto rat, congenic…

Comparison

Genetic mapping and congenic experimentation of… vs Normotensive WKY-0HD strain and different…

Design

Preclinical

Authors

RKReinhold KreutzPreventive CardiologyNHNorbert HübnerHeart Failure & TransplantMJMichael R. JamesUniversity of North Carolina at Charlotte

Discussion

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Implication

Dissects composite hypertension locus in rats into basal and salt-sensitive components; leaves open translation to human genetic risk stratification.

Structured PICO

P
Population
Rat models including stroke-prone spontaneously hypertensive rat (SHRSPHD), normotensive Wistar-Kyoto (WKY-0HD) rat, congenic strain WKY-1HD, and F2 crosses.
I
Intervention
Genetic mapping and congenic experimentation of the BP/SP-1 locus on chromosome 10, including exposure to excess dietary NaCl.
C
Comparator
Normotensive WKY-0HD strain and different genetic crosses.
O
Outcome
Blood pressure (basal and after exposure to excess dietary NaCl).surrogate

The genetic locus for hypertension on rat chromosome 10 can be dissected into two distinct components affecting basal and salt-sensitive blood pressure.

Cite This Study

Kreutz et al. (1995) studied this question.

synapsesocial.com/papers/6a7d51baf1daba58ecd5b4f9https://doi.org/10.1073/pnas.92.19.8778

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural alterations of the renin gene in stroke-prone spontaneously hypertensive rats: examination of genotype-phenotype correlations1990 · 65 citations
  2. 2BLOOD PRESSURE AGGREGATION IN FAMILIES1979 · 282 citations
  3. 3Genetic Dissection of Complex Traits1994 · 3,464 citations
  4. 4Rapid determination of sequences flanking microsatellites1991 · 47 citations