What question did this study set out to answer?

The aim is to identify genetic loci associated with blood pressure variations in F2 progeny from hypertensive rat models.

January 1, 1993Journal of Hypertension

A new genetic locus cosegregating with blood pressure in F2 progeny obtained from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats

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Population

F2 progeny obtained from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats of Izumo colony

Comparison

DNA fingerprinting with 26 32P-labelled human… vs Comparison between F2 rats with [ rats] and…

Design

Preclinical

Authors

TNTom NabikaShimane University YNYasuo NaraUniversity of Hyogo KIKatsumi IkedaShimane University

Discussion

Member takes

Implication

A novel BP locus independent of ACE cosegregates in hypertensive rats; leaves open relevance to human hypertension.

Key Points

The aim is to identify genetic loci associated with blood pressure variations in F2 progeny from hypertensive rat models.
Obtained F2 progeny from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats.
Measured blood pressure using a photoelectronic oscillometric tail-cuff method before and during salt loading.
Performed DNA fingerprinting using 26 human variable number of tandem repeats markers to analyze genetic variances.
Identified 87 polymorphic fingerprint bands between SHRSP and WKY rats.
One specific band (1/MCT96.1) showed a significant distorted distribution correlated with blood pressure levels in F2 rats.
Rats without the 1/MCT96.1 band exhibited significantly higher blood pressures compared to those with the band.

Structured PICO

Population

F2 progeny obtained from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats of Izumo colony

Intervention

DNA fingerprinting with 26 32P-labelled human variable number of tandem repeats markers

Comparator

Comparison between F2 rats with [(+) rats] and without [(-) rats] the 1/MCT96.1 band

Outcome

Blood pressure before and during salt loadingsurrogate

Identified a novel genetic locus distinct from the ACE region that cosegregates with blood pressure in a hypertensive rat model.

Cite This Study

Nabika et al. (1993) studied this question.

synapsesocial.com/papers/6a7a0f5fbdf697b3de027ce2 https://doi.org/10.1097/00004872-199301000-00003

Topics

Hypertension management

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A new genetic locus cosegregating with blood pressure in F2 progeny obtained from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A new genetic locus cosegregating with blood pressure in F2 progeny obtained from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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