Key result
Genome-wide screening in 578 rats identified five chromosomal regions with significant linkage to blood pressure, with the strongest linkage on rat chromosome 1 (maximum LOD score 8.3).
Population
578 F2 rats derived from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats of a Japanese…
Design
Preclinical
Follow-up
up to 5 months of age
Authors
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Hypothesis-generating for hypertension genetics; leaves open translation to human risk or therapy.
Effect estimate: LOD score 8.3
Genome-wide screening in a Japanese colony of stroke-prone spontaneously hypertensive rats identified strong linkage of blood pressure to chromosome 1, emphasizing the role of age, sex, and diet in genetic studies.
Kato et al. (2003) studied Blood pressure quantitative trait loci (n=578). Genome-wide screen for blood pressure quantitative trait loci was evaluated on Linkage to blood pressure at 13 weeks of age (LOD score 8.3). Genome-wide screening in 578 rats identified five chromosomal regions with significant linkage to blood pressure, with the strongest linkage on rat chromosome 1 (maximum LOD score 8.3).
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