Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows no linkage to the angiotensinogen locus.

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Population

115 F2 hybrids bred from stroke-prone spontaneously hypertensive rats and a normotensive reference strain…

Design

Preclinical

Authors

Discussion

Angiotensinogen shows no BP linkage in this rat model; leaves open species-specific genetic mechanisms versus human hypertension.

Population

115 F2 hybrids bred from stroke-prone spontaneously hypertensive rats (SHRSPHD) and a normotensive reference strain, the Wistar-KyotoHD (WKYHD) rat

Intervention

Genetic linkage analysis of the angiotensinogen gene locus using a polymorphic marker assay

Outcome

Cosegregation between the angiotensinogen gene locus and blood pressure (systolic and diastolic) or heart ratesurrogate

Unlike in humans, blood pressure in the stroke-prone spontaneously hypertensive rat model does not show genetic linkage to the angiotensinogen locus.

Hübner et al. (1994) studied this question.

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