December 1, 2002Journal of Hypertension

Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains

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Population

F2 population derived from two genetically hypertensive rat strains, the Dahl salt-sensitive rat and the…

Design

Preclinical

Follow-up

5 weeks

Authors

MGMichael R. GarrettUniversity of Mississippi Medical Center BJBina JoeUniversity of Toledo HDHoward DeneUniversity of Toledo Medical Center

Discussion

Member takes

Implication

Does not inform clinical hypertension care; leaves open whether these rat QTLs advance human BP genetics or therapy.

Structured PICO

Population

F2 population derived from two genetically hypertensive rat strains, the Dahl salt-sensitive (S) rat and the Albino Surgery (AS) rat

Intervention

Genome scan using 222 genetic markers after feeding 8% NaCl for 5 weeks

Outcome

Blood pressure quantitative trait loci (QTL)surrogate

The study identifies three distinct genomic regions (chromosomes 2, 4, and 8) that differentially regulate blood pressure between two hypertensive rat strains, including a newly discovered locus on chromosome 4.

Cite This Study

Garrett et al. (2002) studied this question.

synapsesocial.com/papers/6a6fafe6ac440176ef285874 https://doi.org/10.1097/00004872-200212000-00019

Topics

Hypertension management

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