Population
10 congenic strains of Dahl salt-sensitive (DSS) rats and Lewis (LEW) rats
Comparison
Replacement of various segments of chromosome 10… vs Dahl salt-sensitive (DSS) rat
Design
Preclinical
Authors
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Refines rat hypertension QTL intervals; extends genetic mapping but leaves clinical translation open.
High-resolution mapping in congenic rat strains identified three blood pressure QTLs on chromosome 10, disqualifying Nos2 and Ace as candidates in this model.
Palijan et al. (2003) studied this question.
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