What question did this study set out to answer?

Localize blood pressure quantitative trait loci (QTL) on chromosome 10 in a Dahl salt-sensitive rat model of human hypertension.

January 1, 2002Journal of Hypertension

Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats

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Population

Dahl salt-sensitive (S) rats and Lewis (LEW) rats used to construct four congenic strains

Comparison

Replacement of various segments of chromosome 10… vs Dahl salt-sensitive (S) rat

Design

Preclinical

Authors

ZSZsuzsa SivoCentre Hospitalier de l’Université de Montréal BMBrigitte MaloHôtel-Dieu de Montréal JDJulie DutilNational Institutes of Health

Discussion

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Implication

Refines rat models for hypertension genetics and hypertrophy; leaves open human translation and clinical relevance.

Key Points

Localize blood pressure quantitative trait loci (QTL) on chromosome 10 in a Dahl salt-sensitive rat model of human hypertension.
Constructed four congenic rat strains by introgressing segments of chromosome 10 from Lewis rats into Dahl salt-sensitive rats using marker-assisted selection.
Measured arterial blood pressure across congenic strains via telemetry and evaluated intermediate phenotypes including cardiac, vascular, and renal hypertrophy.
Mapped two distinct blood pressure QTL on chromosome 10: QTL1 within a 4.2 cM region and QTL2 within a region of less than 12.1 cM.
Demonstrated that both QTL correlate with cardiac, left ventricular, and aortic hypertrophy, while QTL1 uniquely associates with renal hypertrophy.

Structured PICO

Population

Dahl salt-sensitive (S) rats and Lewis (LEW) rats used to construct four congenic strains

Intervention

Replacement of various segments of chromosome 10 of the Dahl salt-sensitive (S) rat with those of the Lewis (LEW) rat

Comparator

Dahl salt-sensitive (S) rat

Outcome

Blood pressure measured by telemetrysurrogate

The identification of multiple blood pressure quantitative trait loci on chromosome 10 in Dahl rats provides an animal model to help unravel the genetic mechanisms underlying hypertension.

Cite This Study

Sivo et al. (2002) studied this question.

synapsesocial.com/papers/6a6fafe6ac440176ef285877 https://doi.org/10.1097/00004872-200201000-00008

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Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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