Population
Spontaneously hypertensive rats, Wistar-Kyoto rats, and stroke-prone spontaneously hypertensive rats from…
Comparison
DNA fingerprinting using probes to hypervariable… vs Comparison between different stocks/sources and…
Design
Preclinical
Authors
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Variability in WKY controls may confound SHR comparisons across studies; leaves open the need for genetic standardization in hypertension models.
Genetic heterogeneity exists among Wistar-Kyoto rats from different sources, suggesting that experimental results using these rats as controls for spontaneously hypertensive rats may not be directly comparable.
Samani et al. (1989) studied this question.
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