Key result
Wistar-Kyoto rats may be unsuitable controls for spontaneously hypertensive rat studies due to genetic variability.
Why the study?
Genetic differences between colonies of spontaneously hypertensive rats and Wistar-Kyoto rats raise concerns about their suitability for genetic studies of hypertension.
Population
Spontaneously hypertensive rat and Wistar-Kyoto rat strains from various colonies worldwide
Comparison
Genetic variability between SHR and WKY rat colonies
Design
Review article detailing strain history and genetic variability
Authors
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WKY controls may compromise validity of SHR backcross studies; leaves open identification of standardized reference strains for hypertension genetics research.
Highlights genetic variability in SHR and WKY rat colonies and proposes a standardized central reference strain for hypertension research.
Louis et al. (1990) conducted a review in Hypertension (animal model). Spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rat strains was evaluated. The Wistar-Kyoto rat strain may not be the most suitable control for backcross studies of spontaneously hypertensive rats due to genetic variability and spontaneous hypertension incidence.
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