Key result
Hyperactive rat strains exhibited enhanced cardiovascular responses to stress and higher heart rates, indicating that cardiovascular reactivity to stress is related to behavioral traits.
Population
Male spontaneously hypertensive rats, Wistar-Kyoto rats, Wistar-Kyoto hypertensive, and Wistar-Kyoto…
Comparison
Air-jet stress and pharmacological interventions vs Comparison across the four different rat strains…
Design
Preclinical
Authors
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Animal models dissociate hypertensive and hyperactive traits; leaves open whether CVR to stress tracks with hypertension clinically.
In a rat model, enhanced cardiovascular reactivity to stress is primarily associated with behavioral hyperactivity rather than the hypertensive trait.
Knardahl et al. (1990) studied Hypertension and behavioral hyperactivity. Air-jet stress and pharmacological interventions vs. WKY rats was evaluated on Cardiovascular reactivity (pressor, renal, and mesenteric responses to stress, and heart rate). Hyperactive rat strains exhibited enhanced cardiovascular responses to stress and higher heart rates, indicating that cardiovascular reactivity to stress is related to behavioral traits.
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