Key result
Restraint stress caused tachycardia and pressor responses that were greater in spontaneously hypertensive rats compared with normotensive rats, indicating an impaired coping mechanism in hypertension.
Why the study?
Does restraint stress affect cardiovascular regulation differently in spontaneously hypertensive rats compared to normotensive rats?
Population
Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)
Comparison
Acute or chronic stress vs No-restraint (control)
Design
Preclinical
Follow-up
10 days
Authors
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Basal hemodynamics unchanged by chronic restraint in SHR; leaves open translation to human stress-hypertension mechanisms.
Does restraint stress affect cardiovascular regulation differently in spontaneously hypertensive rats compared to normotensive rats?
Spontaneously hypertensive rats exhibit an impaired coping mechanism to restraint stress compared to normotensive rats, suggesting that a reduced capacity to cope with stress may affect cardiovascular regulation in hypertension.
McDougall et al. (2000) studied Hypertension. Restraint stress vs. No-restraint (control) was evaluated on Heart rate and blood pressure (tachycardia and pressor responses). Restraint stress caused tachycardia and pressor responses that were greater in spontaneously hypertensive rats compared with normotensive rats, indicating an impaired coping mechanism in hypertension.
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