Key result
The chromosome 1 blood pressure QTL congenic rat (WKYpch1.0) exhibited sympathetic hyperreactivity and exaggerated pressor responses to air-jet stress, partly mediated by the brain RAS.
Population
Chromosome 1 blood pressure quantitative trait locus congenic rats, Wistar-Kyoto rats, and stroke-prone…
Comparison
Air-jet stress with or without… vs WKY and SHRSP rats
Design
Preclinical
Authors
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Hypothesis-generating for brain RAS in stress-induced hypertension models; human translation and clinical relevance remain untested.
The chromosome 1 blood pressure QTL congenic rat exhibits sympathetic hyperreactivity to stress, which causes exaggerated pressor responses that are at least partly mediated by the brain renin-angiotensin system.
Yamazato et al. (2005) studied Sympathetic hyperreactivity and blood pressure regulation. Air-jet stress and intracerebroventricular candesartan vs. WKY and SHRSP rats was evaluated on Mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) responses. The chromosome 1 blood pressure QTL congenic rat (WKYpch1.0) exhibited sympathetic hyperreactivity and exaggerated pressor responses to air-jet stress, partly mediated by the brain RAS.
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