Why the study?
Does losartan or prazosin alter blood pressure and heart rate variability responses to stress in SHR and WKY rats?
Population
Spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Chronic treatment with losartan or acute… vs Untreated animals
Design
Preclinical
Authors
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Sympathetic but not RAS pathways appear essential for stress BP rises in rats; hypothesis-generating and should not yet change practice.
Does losartan or prazosin alter blood pressure and heart rate variability responses to stress in SHR and WKY rats?
The sympathetic nervous system, but not the renin-angiotensin system, is essential for stress-induced blood pressure rises, while both are involved in blood pressure and heart rate variability changes.
Gaudet et al. (1996) studied this question.
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