Key result
Chronic treatment with losartan reduced resting systolic blood pressure by 20 mmHg in SHR rats and abolished stress-induced blood pressure and heart rate variability changes in both strains.
Population
WKY (Wistar-Kyoto) and SHR (Spontaneously Hypertensive Rats) animal models
Comparison
Chronic treatment with losartan vs Untreated animals
Design
Preclinical
Authors
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May guide ARB research on autonomic stress responses; leaves open translation from rodent models to clinical practice.
Losartan inhibits stress-induced blood pressure and heart rate variability changes in both normotensive and hypertensive rats, highlighting the role of angiotensin II-sympathetic interaction.
Gaudet et al. (1997) studied Stress-induced blood pressure and heart rate variability. Losartan vs. Untreated animals was evaluated on Blood pressure and heart rate variability responses during air-jet stress. Chronic treatment with losartan reduced resting systolic blood pressure by 20 mmHg in SHR rats and abolished stress-induced blood pressure and heart rate variability changes in both strains.
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