October 1, 1991Clinical and Experimental Pharmacology and Physiology

Effects of Clonidine on Blood Pressure and Heart Rate Responses to an Emotional Stress in the Rat: A Spectral Study

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Why the study?

Does clonidine prevent blood pressure and heart rate responses to emotional stress in normotensive rats?

Population

Conscious normotensive rats

Comparison

Clonidine prior to air jet stimulation vs Air jet stimulation without clonidine

Design

Preclinical

Authors

JBJocelyne BlancCentre National de la Recherche Scientifique MGMarie‐Laure GrichoisCentre National de la Recherche Scientifique JEJean‐Luc ElghoziCross-Cutting Cardiology

Discussion

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Implication

Clonidine blunts sympathetic responses to emotional stress in rats; leaves open human translation and clinical relevance.

Structured PICO

Does clonidine prevent blood pressure and heart rate responses to emotional stress in normotensive rats?

Population

Conscious normotensive rats

Intervention

Clonidine (10 micrograms/kg, i.v.) prior to air jet stimulation

Comparator

Air jet stimulation without clonidine (baseline/control state)

Outcome

Blood pressure and heart rate responses and their spectral variability (195-605 mHz oscillations)surrogate

Clonidine blunts the sympathetic hyperactivity and blood pressure elevation induced by mild emotional stress in a rat model.

Cite This Study

Blanc et al. (1991) studied this question.

synapsesocial.com/papers/6a85c79a02a1bc3ea31e76c8 https://doi.org/10.1111/j.1440-1681.1991.tb01385.x

View Full Paper

Ask AI

Bookmark

Effects of Clonidine on Blood Pressure and Heart Rate Responses to an Emotional Stress in the Rat: A Spectral Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Clonidine on Blood Pressure and Heart Rate Responses to an Emotional Stress in the Rat: A Spectral Study

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider