Why the study?
Does clonidine reduce blood pressure and heart rate oscillations in conscious rats?
Population
Conscious rats
Comparison
Clonidine 10 micrograms/kg i.v. vs Control value (baseline)
Design
Preclinical
Follow-up
20 min
Authors
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Attenuates variability in conscious rats; extends preclinical models but leaves open human translation.
Does clonidine reduce blood pressure and heart rate oscillations in conscious rats?
Clonidine significantly reduces the spontaneous variability of blood pressure and heart rate in conscious rats, likely due to increased baroreflex sensitivity.
Grichois et al. (1990) studied this question.
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