Key result
Intravenous clonidine reduces standing HRV ~30% versus placebo in healthy men.
Why the study?
Does intravenous clonidine affect heart rate variability in healthy male controls?
RCT (n=10)
Double-blind
No
Does intravenous clonidine affect heart rate variability in healthy male controls?
Intravenous clonidine significantly decreases blood pressure and heart rate variability during quiet standing in healthy males.
Answers are grounded in this paper and cite their sources.
Should not change practice in patients; hypothesis-generating for autonomic effects in cardiovascular disease.
We compared the effects of intravenous infusions of clonidine and placebo on heart rate variability in 10 healthy male controls. Clonidine produced a significant decrease in blood pressure and significantly decreased the heart rate variability during quiet standing.
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Yeragani et al. (1992) conducted an RCT in Healthy (n=10). Clonidine vs. Placebo was evaluated on Heart rate variability (MCDC) during quiet standing (p=<0.05). Intravenous clonidine significantly decreased heart rate variability during quiet standing compared to placebo in healthy male volunteers.
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