Why the study?
Does oral clonidine improve regional and central hemodynamic variables in patients with congestive heart failure?
Does oral clonidine improve regional and central hemodynamic variables in patients with congestive heart failure?
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Clonidine significantly reduces preload and afterload in patients with congestive heart failure without markedly altering regional blood flow or cardiac index.
Regional and central hemodynamic variables were ascertained in 10 patients with congestive heart failure before and after the oral administration of clonidine. Following the 0.2 mg dose, renal, hepatic, and limb blood flow remained unaltered, whereas a reduction was noted in heart rate (10%), mean systemic (14%), and pulmonary capillary wedge pressures (27%). Cardiac index and systemic vascular resistance fell slightly, however the changes were not statistically significant. Higher dose clonidine (0.4 mg) elicited similar regional hemodynamic effects whereas systemic vascular resistance significantly diminished (21%) and cardiac index remained unchanged. In congestive heart failure, the central antihypertensive agent, clonidine, effects a significant reduction in preload (left ventricular filling pressure) and afterload (systemic blood pressure) without markedly altering other central and regional hemodynamic variables.
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Magorien et al. (1985) studied this question.
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