Why the study?
Does transdermal clonidine reduce sympathetic nerve traffic and plasma norepinephrine in normotensive patients with congestive heart failure?
Population
26 normotensive patients with congestive heart failure, mean age 58.0+/-1.1 years, treated with furosemide…
Comparison
Transdermal clonidine patch for 2 months vs Transdermal placebo patch for 2 months
Design
RCT, randomized sequence, double-blind
Follow-up
2 months
Authors
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Transdermal clonidine may suppress sympathetic overactivity in heart failure without baroreflex impairment; extends sympatholytic evidence from this RCT to normotensive patients.
Does transdermal clonidine reduce sympathetic nerve traffic and plasma norepinephrine in normotensive patients with congestive heart failure?
In patients with congestive heart failure on standard therapy, chronic transdermal clonidine administration significantly reduces sympathetic overactivity without adversely affecting cardiac function.
Grassı et al. (2001) studied this question.
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