Why the study?
Does sympathoinhibition with clonidine improve skeletal muscle blood flow and metabolism during exercise in patients with chronic heart failure?
Population
20 patients with chronic heart failure and exercise intolerance
Comparison
Clonidine 2 micrograms/kg IV administered 2… vs 0.9% normal saline administered 2 hours before…
Design
Other
Follow-up
2 hours
Authors
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May support sympathoinhibition testing for HF exercise intolerance; hypothesis-generating and should not yet change practice.
Does sympathoinhibition with clonidine improve skeletal muscle blood flow and metabolism during exercise in patients with chronic heart failure?
Sympathoinhibition with clonidine improves leg blood flow and muscle efficiency during exercise in patients with chronic heart failure, suggesting excessive sympathetic activation impairs exercise performance.
Lang et al. (1997) studied this question.
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