Why the study?
Does a single oral dose of clonidine plus captopril improve hemodynamic and hormonal parameters in patients with Class III or IV congestive heart failure compared to captopril plus placebo?
Does a single oral dose of clonidine plus captopril improve hemodynamic and hormonal parameters in patients with Class III or IV congestive heart failure compared to captopril plus placebo?
The addition of a single dose of clonidine to captopril provides additive hemodynamic and hormonal benefits, significantly improving preload and afterload in severe heart failure.
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May support short-term hemodynamic improvement in severe HF; leaves open need for outcome trials.
Manolis et al. (1997) studied this question.