Population
Conscious rats
Comparison
Clonidine administered intracerebroventricularly… vs Intravenous vs intracerebroventricular…
Design
Preclinical
Authors
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Route-specific clonidine effects in rats warrant caution extrapolating to patients; extends central sympatholytic understanding but leaves open clinical translation.
In conscious rats, centrally administered clonidine produces pressor and tachycardic actions, with the tachycardia mediated by inhibition of parasympathetic tone.
Imai et al. (1986) studied this question.
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