Key result
A restricted daytime clonidine regimen significantly decreased blood pressure and heart rate during 8-hour exposure periods over 12 weeks in spontaneously hypertensive rats without causing tolerance.
Why the study?
Does an intermittent clonidine regimen prevent tolerance to its antihypertensive effect in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHRs)
Comparison
Clonidine administered via liquid diet during a… vs Pair-fed SHRs receiving liquid diets without…
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for intermittent clonidine to avert tolerance; requires human trials before any practice consideration.
Does an intermittent clonidine regimen prevent tolerance to its antihypertensive effect in spontaneously hypertensive rats?
An intermittent clonidine regimen abolishes tolerance to its antihypertensive effect and prevents rebound hypertension in a rat model.
El‐Mas et al. (2007) studied Hypertension. Intermittent clonidine regimen vs. Liquid diet without clonidine was evaluated on Blood pressure, heart rate, and myocardial contractility. A restricted daytime clonidine regimen significantly decreased blood pressure and heart rate during 8-hour exposure periods over 12 weeks in spontaneously hypertensive rats without causing tolerance.
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