What question did this study set out to answer?

The aim is to investigate the effects of prolonged clonidine treatment on catecholamine levels and blood pressure in patients with essential hypertension.

January 12, 1981Acta Medica Scandinavica

Prolonged Clonidine Treatment: Catecholamines, Renin Activity and Aldosterone Following Exercise in Hypertensives

View Full Paper

Ask AI

Bookmark

Why the study?

Does clonidine reduce catecholamines, renin activity, aldosterone, blood pressure, and pulse rate following exercise in patients with essential hypertension?

Population

8 patients with essential hypertension, WHO grade I-III

Comparison

Clonidine 300-600 micrograms/24 h for 8-20 weeks vs Baseline (before clonidine treatment)

Design

Cohort

Follow-up

8-20 weeks

Authors

PMPer ManhemLund University BHB. HökfeltKarolinska Institutet

Discussion

Member takes

Implication

Supports sympatholytic contribution to clonidine's effect in hypertension; leaves open relevance versus modern agents in randomized data.

Key Points

The aim is to investigate the effects of prolonged clonidine treatment on catecholamine levels and blood pressure in patients with essential hypertension.
Eight patients with essential hypertension received clonidine treatment for 8-20 weeks at a dose of 300-600 micrograms/24 h.
Measurements were taken for plasma noradrenaline, plasma adrenaline, plasma renin activity, and plasma aldosterone before and after treatment.
The study was conducted in a metabolic ward under standardized conditions.
Clonidine treatment significantly reduced blood pressure and pulse rate in all conditions.
Plasma noradrenaline and plasma renin activity decreased, showing correlations with decreases in diastolic blood pressure (R = 0.76, p < 0.05).
Plasma adrenaline levels were lower post-treatment in both supine and upright positions, indicating inhibited sympatho-adreno-medullary system activity.

Structured PICO

Does clonidine reduce catecholamines, renin activity, aldosterone, blood pressure, and pulse rate following exercise in patients with essential hypertension?

Population

8 patients with essential hypertension, WHO grade I-III

Intervention

Clonidine 300-600 micrograms/24 h for 8-20 weeks

Comparator

Baseline (before clonidine treatment)

Outcome

Plasma noradrenaline concentration (PNA), plasma adrenaline concentration (PA), plasma renin activity (PRA), plasma aldosterone concentration (PAC), blood pressure, and pulse rate in response to standing and submaximal exercise for 20 minsurrogate

Long-term clonidine treatment lowers blood pressure and pulse rate in hypertensive patients partly by reducing sympathetic activity, without blocking sympathetic reflex mechanisms during upright posture.

Cite This Study

Manhem et al. (1981) studied this question.

synapsesocial.com/papers/6a761f569aebbbed36614434 https://doi.org/10.1111/j.0954-6820.1981.tb11587.x

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Prolonged Clonidine Treatment: Catecholamines, Renin Activity and Aldosterone Following Exercise in Hypertensives

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Prolonged Clonidine Treatment: Catecholamines, Renin Activity and Aldosterone Following Exercise in Hypertensives

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider