Why the study?
Does clonidine reduce central and peripheral catecholamine levels in primary hypertensive subjects?
Population
10 primary hypertensive subjects
Comparison
Clonidine treatment for 3 months vs Baseline (before treatment)
Design
Cohort
Follow-up
3 months
Authors
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Supports clonidine's central and peripheral sympatholytic mechanism in hypertension; leaves open causal confirmation and outcome impact in randomized trials.
Does clonidine reduce central and peripheral catecholamine levels in primary hypertensive subjects?
Clonidine lowers blood pressure by decreasing both central and peripheral norepinephrine activity.
Sullivan et al. (1986) studied this question.
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