Key result
Oral clonidine induces variations in plasma norepinephrine, mean arterial pressure, and pulse rate in patients with essential hypertension.
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Requires hemodynamic monitoring during oral clonidine initiation in hypertension; leaves open comparative efficacy in contemporary practice.
To assess the contribution of sympathetic outflow to blood pressure in patients with essential hypertension, clonidine induced variations of plasma norepinephrine, mean arterial pressure and the pulse rate three hours after a 300 μg dose of oral clonidine, an antihypertensive agent that decreases central sympathetic outflow, were studied.
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Lee et al. (1987) studied this question. Oral clonidine induces variations in plasma norepinephrine, mean arterial pressure, and pulse rate in patients with essential hypertension.
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