Why the study?
Does oral clonidine reduce plasma norepinephrine appearance rate or increase clearance in normal subjects?
Population
14 normal (normotensive) subjects (n=10 for clonidine, n=4 for placebo), aged 25-56 years.
Comparison
Oral clonidine at 1.5 micrograms/kg and 5.0… vs Placebo administration using an identical…
Design
Other
Follow-up
120-140 minutes
Authors
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Clonidine suppresses NE appearance dose-dependently in normals; leaves open translation to patients with hypertension or HF.
Does oral clonidine reduce plasma norepinephrine appearance rate or increase clearance in normal subjects?
Clonidine lowers plasma norepinephrine levels through a dose-dependent suppression of its appearance rate rather than increased clearance, demonstrating alpha-2 adrenergic inhibition of sympathetic activity.
Veith et al. (1984) studied this question.
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