May 1, 1987Journal of Gerontology

Age and Alpha-2 Adrenergic Regulation of Plasma Norepinephrine Kinetics in Humans

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Why the study?

Does oral clonidine affect plasma norepinephrine kinetics differently in old versus young normotensive men?

Structured PICO

Does oral clonidine affect plasma norepinephrine kinetics differently in old versus young normotensive men?

Population

14 normotensive male volunteers, comprising 6 old (57 to 78 years) and 8 young (25 to 39 years) men.

Intervention

Oral clonidine 1.5 and 5.0 micrograms/kg

Comparator

Baseline measurements and comparison between old and young age groups

Outcome

Arterialized plasma norepinephrine (NE) kinetics (plasma NE, NE appearance rate, NE clearance) and mean arterial blood pressure (MAP) measured 120 to 140 min after clonidine administrationsurrogate

Sensitivity to alpha-2 receptor-mediated suppression of plasma norepinephrine and its appearance is not diminished in elderly men, despite their higher baseline levels.

Discussion

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Implication

Greater MAP fall after clonidine in older men warrants dosing caution; supports preserved alpha-2 sensitivity despite aging.

Cite This Study

Featherstone et al. (1987) studied this question.

synapsesocial.com/papers/6a9814db5a0f36424c367ada https://doi.org/10.1093/geronj/42.3.271

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Age and Alpha-2 Adrenergic Regulation of Plasma Norepinephrine Kinetics in Humans

Structured PICO

Discussion

Implication

Cite This Study

Age and Alpha-2 Adrenergic Regulation of Plasma Norepinephrine Kinetics in Humans

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider