Why the study?
Does suppression of sympathetic nervous system tone with guanadrel improve alpha-adrenergic agonist-mediated venoconstriction in older healthy subjects?
Population
15 older healthy subjects (age 59-73 yr)
Comparison
Guanadrel 15 mg twice daily for 3 weeks vs Placebo
Follow-up
3 weeks
Authors
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Indicates age-related impairment in alpha1-adrenergic venoconstriction regulation; hypothesis-generating for SNS modulation in older adults.
Does suppression of sympathetic nervous system tone with guanadrel improve alpha-adrenergic agonist-mediated venoconstriction in older healthy subjects?
Suppression of sympathetic nervous system tone in older adults upregulates alpha 2-adrenergic but not alpha 1-adrenergic venoconstriction, suggesting impaired regulation of alpha 1 responses with aging.
Supiano et al. (1991) studied this question.
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