Key result
Older age is associated with reduced leg postjunctional alpha-adrenoceptor responsiveness, including lower maximal vasoconstriction to phenylephrine (-25% vs -45%, P<0.05).
Why the study?
Does ageing reduce leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men?
Cross-Sectional (n=19)
Does ageing reduce leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men?
Absolute Event Rate: -25% vs -45%
p-value: p=<0.05
Ageing is associated with reduced leg postjunctional alpha-adrenoceptor responsiveness to endogenous noradrenaline release, though this does not negate greater tonic sympathetic vasoconstriction in older men.
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May influence age-related vascular control models; leaves open clinical relevance for BP regulation or orthostatic tolerance.
Smith et al. (2007) conducted a cross-sectional in Healthy (n=19). Older age (Ageing) vs. Young age was evaluated on Maximal vasoconstrictor response to phenylephrine (alpha1-agonist) (p=<0.05). Older age is associated with reduced leg postjunctional alpha-adrenoceptor responsiveness, including lower maximal vasoconstriction to phenylephrine (-25% vs -45%, P<0.05).
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