Key result
Older adults showed reduced sympatholysis during exercise compared to young adults (32% vs 74% for α1-stimulation; P<0.05), but the sympatholytic effect of exogenous ATP was preserved in both groups.
Why the study?
Does ageing impair the modulation of postjunctional α-adrenergic vasoconstriction to exogenous ATP and exercise in healthy adults?
Population
14 healthy adults, comprising 7 older (64 ± 3 years) and 7 young (22 ± 1 years) individuals.
Comparison
Intra-arterial infusions of phenylephrine and… vs Young vs. older adults across different…
Design
Cross-sectional
Authors
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Supports reduced circulating ATP as contributor to age-related sympatholysis impairment; hypothesis-generating for targeted interventions in older adults.
Cross-Sectional (n=14)
Does ageing impair the modulation of postjunctional α-adrenergic vasoconstriction to exogenous ATP and exercise in healthy adults?
Absolute Event Rate: 32% vs 74%
p-value: p=<0.05
The ability to modulate postjunctional α-adrenergic vasoconstriction during exercise is impaired with age, but the sympatholytic effect of exogenous ATP is preserved, suggesting that age-related impairments in vascular control may involve reduced circulating ATP.
Kirby et al. (2011) conducted a cross-sectional in Healthy adults (n=14). Intra-arterial infusions of phenylephrine, dexmedetomidine, adenosine, and ATP during exercise vs. Young adults was evaluated on Magnitude of sympatholysis (reduction in α1-mediated vasoconstriction during exercise) (p=<0.05). Older adults showed reduced sympatholysis during exercise compared to young adults (32% vs 74% for α1-stimulation; P<0.05), but the sympatholytic effect of exogenous ATP was preserved in both groups.
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