Key result
A single clonidine dose lowers systolic BP by ~20 mmHg in healthy normotensive subjects.
Why the study?
Does a single oral dose of clonidine lower blood pressure and sympathetic nervous activity in healthy normotensive subjects?
Population
7 healthy normotensive subjects
Comparison
Single oral dose of clonidine hydrochloride vs Control, drug-free day under the same conditions…
Design
Other
Follow-up
12 hours
Authors
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Clonidine acutely suppresses sympathetic activity without rebound in normotensives; leaves open translation to hypertensive or HF populations.
Does a single oral dose of clonidine lower blood pressure and sympathetic nervous activity in healthy normotensive subjects?
A single dose of clonidine lowers blood pressure and sympathetic nervous activity in normotensive subjects without an overshoot of sympathetic activity at 12 hours.
Wing et al. (1977) studied Healthy normotensive (n=7). Clonidine hydrochloride vs. Control, drug-free day was evaluated on Blood pressure, plasma noradrenaline concentration, and plasma renin activity. A single oral dose of clonidine (300 microgram) lowered systolic blood pressure by 20+/-2 mmHg and diastolic blood pressure by 15+/-2 mmHg in healthy normotensive subjects.
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