What question did this study set out to answer?

To determine the effects of single and repeated doses of clonidine on circulating plasma catecholamine levels, blood pressure, and flushing in humans.

January 1, 1978The Journal of Clinical Endocrinology & Metabolism

Suppression of Plasma Catecholamines and Flushing by Clonidine in Man*

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Why the study?

Does clonidine reduce plasma catecholamines and flushing in normal male volunteers and patients with metabolic disorders?

Population

Normal male volunteers and 5 patients with various metabolic disorders

Comparison

Clonidine as a single oral dose or as multiple… vs Basal levels (pre-treatment)

Design

Other

Follow-up

4 days

Authors

SMStewart A. MetzRoche (Switzerland)JHJeffrey B. HalterNational University of Singapore DPDANIEL PORTEVA Puget Sound Health Care System

Discussion

Member takes

Implication

Supports central alpha-adrenergic mechanism; leaves open clinical role for flushing in metabolic disorders.

Key Points

To determine the effects of single and repeated doses of clonidine on circulating plasma catecholamine levels, blood pressure, and flushing in humans.
Administered clonidine either as a single oral dose (0.5 mg) or multiple doses (0.2–0.4 mg/day for 4 days) to normal male volunteers and 5 patients with various metabolic disorders.
Measured plasma catecholamine levels, mean arterial blood pressure, pressor sensitivity to exogenous norepinephrine infusions, and the antagonistic effect of phentolamine.
Clonidine significantly reduced plasma catecholamines by 81 ± 3% following a single dose and 68 ± 5% following multiple doses (both P < 0.001), with the decrements correlating significantly with basal catecholamines (P < 0.001) and mean arterial pressure reductions (P < 0.001).
Phentolamine reversed catecholamine suppression (clonidine alone = -68 ± 5% vs. clonidine with phentolamine = -1 ± 16%).
Endogenous adrenergic flushing was blocked by clonidine alongside an increased pressor sensitivity to exogenous norepinephrine, whereas flushing caused by exogenous catecholamines was intensified.

Structured PICO

Does clonidine reduce plasma catecholamines and flushing in normal male volunteers and patients with metabolic disorders?

Population

Normal male volunteers and 5 patients with various metabolic disorders

Intervention

Clonidine as a single (0.5 mg) oral dose or as multiple doses (0.2-0.4 mg/day for 4 days)

Comparator

Basal levels (pre-treatment)

Outcome

Plasma catecholamine levelssurrogate

Clonidine significantly reduces plasma catecholamines and blocks flushing associated with endogenous adrenergic discharge, supporting its action via central alpha-adrenergic receptors.

Cite This Study

Metz et al. (1978) studied this question.

synapsesocial.com/papers/6a706384ac440176ef290d36 https://doi.org/10.1210/jcem-46-1-83

Topics

Hypertension management

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Suppression of Plasma Catecholamines and Flushing by Clonidine in Man*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Suppression of Plasma Catecholamines and Flushing by Clonidine in Man*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider