Key result
Prolonged clonidine administration in spontaneously hypertensive rats significantly reduced systolic blood pressure without significantly altering cerebral norepinephrine or renal angiographic findings.
Why the study?
Does prolonged administration of clonidine reduce blood pressure and alter cerebral norepinephrine content or renal vascular structures in spontaneously hypertensive rats?
Does prolonged administration of clonidine reduce blood pressure and alter cerebral norepinephrine content or renal vascular structures in spontaneously hypertensive rats?
Prolonged clonidine administration significantly reduces systolic blood pressure in spontaneously hypertensive rats without significantly altering cerebral norepinephrine content or renal vascular structures.
Suggests clonidine lowers BP independently of cerebral norepinephrine in rats; hypothesis-generating for mechanisms and renal safety, needs clinical trials.
The effects of clonidine on blood pressure, cerebral norepinephrine content and vascular structures of the kidneys were investigated in 21 SHR. Although the body weight was not affected by long term clonidine treatment up to 36 weeks, the syatolic blood pressure was significantly reduced. The reduction of the blood pressure was already obvious after 1 week administration of clonidine but the effect was more prominent after long term treatment of 30 weeks or longer. 2. The cerebral norepinephrine content was significantly lower in SHR, regardless of with or without clonidine treatment, than in the control Wistar rats. Although the cerebral norepinephrine content was slightly increased following clonidine treatment SHR, the increase was not statistically significant. 3. Angiographic study of the kidneys revealed a poor opacification of the blood vessels and glomeruli in SHR compared with the control Wistar rats. There was no difference in the sizes of the arcuate and interlobular arteries in SHR and the control Wistar rats, although the medial muscular hypertrophy of the arteries was slightly more prominent in the SHR histologically. The more prominent in the SHR histologically. The angiographic and histologic findings of the renal arteries were not altered following long term clonidine treatment. A possibility was considered that the renal arterioles are mainly functionally affected in SHR.
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SUGIMOTO et al. (1976) studied Hypertension (Spontaneously Hypertensive Rats) (n=21). Clonidine vs. Control Wistar rats / untreated SHR was evaluated on Blood pressure, cerebral norepinephrine content, and vascular structures of the kidneys. Prolonged clonidine administration in spontaneously hypertensive rats significantly reduced systolic blood pressure without significantly altering cerebral norepinephrine or renal angiographic findings.
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