Key result
Losartan significantly attenuated the mean arterial pressure, heart rate, and renal sympathetic nerve activity responses to carotid occlusion in conscious rabbits (P < 0.01).
Why the study?
Does losartan attenuate the cardiovascular and sympathetic responses to carotid occlusion in conscious rabbits?
Population
7 conscious, aortic depressor nerve-sectioned rabbits
Comparison
Losartan (5 mg/kg i.v.) vs Control
Design
Preclinical
Authors
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AT1 blockade attenuates sympathetic responses to carotid occlusion in rabbits; leaves open clinical relevance for ARBs in human hypertension.
Does losartan attenuate the cardiovascular and sympathetic responses to carotid occlusion in conscious rabbits?
p-value: p=<.01
Losartan attenuates the cardiovascular and sympathetic responses to carotid occlusion in conscious rabbits, indicating that angiotensin II facilitates sympathetic activity via AT1 receptors.
Kumagai et al. (1994) studied this question. Losartan vs. Control (baseline responses) was evaluated on Cardiovascular and renal sympathetic nerve activity responses to carotid occlusion (p=<.01). Losartan significantly attenuated the mean arterial pressure, heart rate, and renal sympathetic nerve activity responses to carotid occlusion in conscious rabbits (P < 0.01).
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