June 1, 1991Hypertension

Effect of angiotensin II antagonism on canine renal sympathetic nerve function.

View Full Paper

Ask AI

Bookmark

Population

Pentobarbital-anesthetized dogs

Design

Preclinical

Authors

PWPancras C. WongPreventive Cardiology SHS D HartDuPont (United States)PTP.B.M.W.M. TimmermansDow Chemical (Belgium)

Discussion

Member takes

Implication

Supports AT1-mediated prejunctional facilitation of renal adrenergic responses in dogs; leaves open translation to human sympathetic modulation by ARBs.

Structured PICO

Population

Pentobarbital-anesthetized dogs

Intervention

Intra-arterial administration of subtype 1-selective Ang II receptor antagonists (DuP 753, EXP3174), subtype 2-selective ligand (PD 123177), captopril, and saralasin

Outcome

Renal vasoconstrictor responses to renal nerve stimulation (RNS) and intrarenal injection of norepinephrinesurrogate

Endogenous angiotensin II enhances renal adrenergic function at the prejunctional site via subtype 1 receptors in anesthetized dogs.

Cite This Study

Wong et al. (1991) studied this question.

synapsesocial.com/papers/6a85b709c670f88be7ae7aa6 https://doi.org/10.1161/01.hyp.17.6.1127

View Full Paper

Ask AI

Bookmark

Implication

Supports AT1-mediated prejunctional facilitation of renal adrenergic responses in dogs; leaves open translation to human sympathetic modulation by ARBs.

Effect of angiotensin II antagonism on canine renal sympathetic nerve function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of angiotensin II antagonism on canine renal sympathetic nerve function.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider