Key result
Repeated immobilization stress induced greater adaptive changes in the cardiovascular and sympatho-adrenal medullary systems of spontaneously hypertensive rats compared to normotensive rats.
Why the study?
Does immobilization stress alter blood pressure, heart rate, and sympatho-adrenal responses differently in spontaneously hypertensive rats compared to normotensive rats?
Population
Spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive male rats
Comparison
Immobilization stress for 1 or 7 periods vs Unstressed SHRs and WKY normotensive rats
Design
Preclinical
Follow-up
7 days
Authors
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Differential stress adaptation in hypertensive rat models should not change practice; leaves open translation to human hypertension.
Does immobilization stress alter blood pressure, heart rate, and sympatho-adrenal responses differently in spontaneously hypertensive rats compared to normotensive rats?
Spontaneously hypertensive rats exhibit greater adaptive changes in cardiovascular and sympatho-adrenal medullary systems in response to repeated immobilization stress compared to normotensive rats.
Květňanský et al. (1979) studied Hypertension. Immobilization stress vs. Wistar-Kyoto (WKY) normotensive rats and unstressed SHRs was evaluated on Blood pressure, heart rate, and circulating levels of norepinephrine, epinephrine, and corticosterone. Repeated immobilization stress induced greater adaptive changes in the cardiovascular and sympatho-adrenal medullary systems of spontaneously hypertensive rats compared to normotensive rats.
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