Key result
High blood pressure stress in spontaneously hypertensive rats significantly attenuated isoproterenol-induced relaxation and increased the response to norepinephrine stimulation in unprotected arteries.
Population
Age-matched male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR), starting at 5 weeks of age.
Comparison
Exposure to high blood pressure stress following… vs Protected ipsilateral femoral artery and…
Design
Preclinical
Follow-up
4 weeks
Authors
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Should not change hypertension management; supports secondary adrenergic vascular changes in animal models and leaves open human translation.
Alterations in vascular alpha- and beta-adrenergic responsiveness in spontaneously hypertensive rats are likely secondary to the increase in blood pressure rather than a primary genetic defect.
Soltis et al. (1984) studied Hypertension. Partial ligation of the left external iliac artery vs. Protected femoral artery and normotensive WKY rats was evaluated on Vascular adrenergic responsiveness (isoproterenol-induced relaxation and norepinephrine stimulation). High blood pressure stress in spontaneously hypertensive rats significantly attenuated isoproterenol-induced relaxation and increased the response to norepinephrine stimulation in unprotected arteries.
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