March 1, 1974Experimental Biology and Medicine
Hemodynamics of the Spontaneously Hypertensive Rat: Effects of Isoproterenol
Key result
Abstract outlines a study on rat myocardial responses to isoproterenol but reports no results.
Why the study?
Does isoproterenol stimulation elicit different hemodynamic and myocardial responses in spontaneously hypertensive rats compared to normotensive rats?
Population
21st and 22nd filial generation of spontaneously hypertensive rats and normotensive Wistar rats ranging from…
Comparison
Beta-adrenergic stimulation with the specific… vs Normotensive Wistar rats receiving the same…
Design
Preclinical
Authors
Discussion
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Implication
No results reported from this animal study; leaves open differential beta-adrenergic responsiveness in hypertensive rat models.
Structured PICO
Does isoproterenol stimulation elicit different hemodynamic and myocardial responses in spontaneously hypertensive rats compared to normotensive rats?
P
Population
Spontaneously hypertensive rats and normotensive Wistar rats aged 22 to 27 weeks studied to evaluate myocardial responses to isoproterenol.
I
Intervention
Beta-adrenergic stimulation with the specific agonist isoproterenol
C
Comparator
Normotensive Wistar rats (NR) receiving the same stimulation
O
Outcome
Hemodynamic and myocardial responses to beta-adrenergic stimulationsurrogate
This preclinical study aimed to evaluate the hemodynamic and myocardial responses of spontaneously hypertensive rats to isoproterenol compared to normotensive controls.
Limitations
- Wistar-Kyoto (WKY) rats were not available at the time this study was initiated, so commercially obtained normotensive Wistar rats were used.
Cite This Study
Pfeffer et al. (1974) studied Hypertension. Isoproterenol vs. Normotensive rats was evaluated on Myocardial response to beta-adrenergic stimulation. The abstract outlines a study to examine the responses of intact normotensive and spontaneously hypertensive rat myocardia to isoproterenol, but does not report any results.