Key result
Prehypertensive spontaneously hypertensive rats exhibited enhanced cardiac sympathetic responsiveness, including a significantly greater release of norepinephrine and a resting tachycardia compared to Wistar-Kyoto controls.
Population
101 age- and weight-matched male rats at 4 weeks of age.
Comparison
Spontaneously hypertensive rat model subjected… vs Wistar-Kyoto (WKY) normotensive control rats.
Design
Preclinical
Authors
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Exaggerated sympathetic responsiveness seen in prehypertensive SHR; hypothesis-generating for early sympathetic drive in hypertension.
Absolute Event Rate: 334% vs 298%
p-value: p=<0.05
In prehypertensive spontaneously hypertensive rats, impaired norepinephrine reuptake leads to enhanced cardiac sympathetic responsiveness and tachycardia before the onset of hypertension.
Shanks et al. (2013) studied Prehypertension (Spontaneously Hypertensive Rat model) (n=101). Spontaneously hypertensive rat (SHR) phenotype vs. Wistar-Kyoto (WKY) rats was evaluated on In vivo resting heart rate under anesthesia (beats/min) (p=<0.05). Prehypertensive spontaneously hypertensive rats exhibited enhanced cardiac sympathetic responsiveness, including a significantly greater release of norepinephrine and a resting tachycardia compared to Wistar-Kyoto controls.
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