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June 27, 2003Journal of Hypertension

Increased cardiac norepinephrine release in spontaneously hypertensive rats

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Population

Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) (n=7 per group)

Comparison

Electrical field stimulation, desipramine, and… vs Wistar-Kyoto rats (WKY)

Design

Preclinical

Authors

CZChristian ZugckDLDirk LoßnitzerJBJohannes Backs

Discussion

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Overview

Suggests alpha-2R impairment drives cardiac sympathetic excess in SHR; hypothesis-generating for human hypertension mechanisms.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) (n=7 per group)
I
Intervention
Electrical field stimulation (1 min, 4 Hz), desipramine (300 nmol/l), and yohimbine (1 micromol/l) in isolated perfused hearts
C
Comparator
Wistar-Kyoto rats (WKY)
O
Outcome
Norepinephrine (NE) overflow from isolated perfused heartssurrogate

Impairment of the alpha-2R mediated presynaptic negative feedback mechanism by reduced expression of the alpha-2R subtype A may increase cardiac net secretion of norepinephrine in spontaneously hypertensive rats.

Cite This Study

Zugck et al. (2003) studied this question.

synapsesocial.com/papers/6a8930dfeb3171c94f2000a8https://doi.org/10.1097/00004872-200307000-00026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gene expression of cardiac beta1-adrenergic receptors during the development of hypertension in spontaneously hypertensive rats1993 · 15 citations
  2. 2Cardiac Sympathetic Nerve Function in Congestive Heart Failure1996 · 454 citations
  3. 3Differential Development of Renal, Doca-salt, and Spontaneous Hypertension in the Rat After Neonatal Sympathectomy1978 · 50 citations
  4. 4Role of α2-adrenergic receptors in hypertension2001 · 30 citations
  5. 5Functional correlates of α2A-adrenoceptor gene polymorphism in the HANE study1999 · 25 citations