Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 2001HypertensionOpen Access

Norepinephrine Reuptake Is Impaired in Skeletal Muscle of Hypertensive Rats In Vivo

View Full Paper
Ask AI
Bookmark
Share

Population

Awake and freely moving normotensive Wistar-Kyoto rats and spontaneously hypertensive rats at 5 weeks and 16…

Comparison

Tissue perfusion of desipramine through… vs Baseline measurements and age-matched…

Design

Preclinical

Follow-up

Evaluated at 5 weeks and 16 weeks of age

Authors

ACAderville CabassiSVSimonetta VinciFQFabio Quartieri

Discussion

Loading...

Member takes

Overview

Highlights NE handling changes in aging SHR; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Awake and freely moving normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) at 5 weeks (prehypertensive) and 16 weeks (hypertensive) of age
I
Intervention
Tissue perfusion of desipramine (norepinephrine reuptake blocker) through microdialysis probes in subcutaneous adipose tissue and skeletal muscle
C
Comparator
Baseline measurements (before blockade) and age-matched normotensive Wistar-Kyoto rats (WKY)
O
Outcome
Norepinephrine (NE) turnover and neuronal NE reuptake activity (measured by plasma and tissue interstitial NE and 3,4-dihydroxyphenylethylene glycol [DHPG])surrogate

In spontaneously hypertensive rats, increased norepinephrine turnover is present early on, and reduced norepinephrine reuptake in skeletal muscle contributes to higher interstitial norepinephrine availability as hypertension develops.

Cite This Study

Cabassi et al. (2001) studied this question.

synapsesocial.com/papers/6a71464f8031ec7bb1dcdc87https://doi.org/10.1161/01.hyp.37.2.698
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic Evidence of Faulty Neuronal Norepinephrine Reuptake in Essential Hypertension2000 · 96 citations
  2. 2Hyperresponsivitiy of spontaneously hypertensive rat to indirect measurement of blood pressure1978 · 179 citations
  3. 3Plasma Adrenaline and Noradrenaline concentrations of the spontaneously hypertensive rat.1981 · 47 citations