What question did this study set out to answer?

To determine whether chronic renal failure alters neuroadrenergic activity and norepinephrine turnover across specific blood pressure-regulating brain nuclei in uremic rats.

May 1, 1994Journal of the American Society of NephrologyOpen Access

Altered norepinephrine turnover in the brown fat of rats with chronic renal failure.

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Authors

RBRoberto BigazziUniversity of Modena and Reggio Emilia EKElla KogosovUniversity of California, Los Angeles VCV. M. CampeseUniversity of Southern California

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Implication

Animal study reveals elevated norepinephrine turnover in central brain nuclei in uremic rats, suggesting central sympathetic nervous system hyperactivity in chronic renal failure.

Key Points

To determine whether chronic renal failure alters neuroadrenergic activity and norepinephrine turnover across specific blood pressure-regulating brain nuclei in uremic rats.
Evaluated Sprague Dawley rats 4 weeks after undergoing 5/6 nephrectomy or sham operations.
Measured neuroadrenergic activity in hypothalamic nuclei, locus coeruleus, and nucleus tractus solitarius by assessing norepinephrine turnover rates 3, 6, and 12 hours after inhibition with L-methyltyrosine.
Endogenous norepinephrine concentrations were significantly higher in uremic rats than in controls within the posterior hypothalamic nuclei (21,501 ± 1,777 vs 12,213 ± 1,404 pg/mg wet weight) and locus coeruleus (16,152 ± 1,114 vs 7,991 ± 622 pg/mg wet weight).
Norepinephrine turnover rates in uremic rats were significantly accelerated in the posterior hypothalamic nuclei (2,150 ± 430 vs 977 ± 244 pg/mg/h; P < 0.05) and locus coeruleus (2,584 ± 323 vs 400 ± 140 pg/mg/h; P < 0.01).
Endogenous norepinephrine levels in the anterior hypothalamic nuclei and nucleus tractus solitarius did not differ significantly between uremic and control groups.

Cite This Study

Bigazzi et al. (1994) studied this question.

synapsesocial.com/papers/6a7170a8febe604dd70a1c01 https://doi.org/10.1681/asn.v4111896

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Implication

Animal study reveals elevated norepinephrine turnover in central brain nuclei in uremic rats, suggesting central sympathetic nervous system hyperactivity in chronic renal failure.

Altered norepinephrine turnover in the brown fat of rats with chronic renal failure.

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Member takes

Implication

Key Points

Cite This Study

Altered norepinephrine turnover in the brown fat of rats with chronic renal failure.

Discussion

Member takes

Implication

Key Points

Cite This Study

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