Why the study?
Does adrenergic stimulation affect the performance of the hypertrophied left ventricle differently in spontaneously hypertensive rats compared to normotensive controls?
Population
Isolated hearts from adult male spontaneously hypertensive rats (SHR)
Comparison
Adrenergic stimulation and variations in… vs Matched normotensive controls (NCR)
Design
Preclinical
Authors
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Hypothesis-generating for enhanced contractile reserve in pressure-overload hypertrophy; does not inform clinical management of human LVH.
Does adrenergic stimulation affect the performance of the hypertrophied left ventricle differently in spontaneously hypertensive rats compared to normotensive controls?
Hypertrophied left ventricles in spontaneously hypertensive rats demonstrate an increased, rather than reduced, maximal contractile capacity under maximal adrenergic stimulation compared to normotensive controls.
Noresson et al. (1982) studied this question.
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