Increased Systolic Performance With Diastolic Dysfunction in Adult Spontaneously Hypertensive Rats
Key result
At 10 to 11 months of age, spontaneously hypertensive rats exhibited higher preload recruitable stroke work compared to Wistar-Kyoto rats (174.5 vs 92.6 mm Hg; P<0.01).
Authors
Discussion
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Implication
Suggests enhanced contractility in chronic hypertension models; leaves open translation to human disease.
PICO
P
Population
10- to 11-month-old spontaneously hypertensive rats and age-matched Wistar-Kyoto rats evaluated for systolic and diastolic function.
E
Exposure / Comparator
Spontaneous hypertension (SHR) vs Wistar-Kyoto rats (WKY)
O
Primary Outcome
Preload recruitable stroke work (PRSW), p=<0.01
Main Result
Absolute Event Rate: 174.5% vs 92.6%
p-value: p=<0.01
Cite This Study
Cingolani et al. (2003) studied Hypertensive heart disease. Spontaneous hypertension (SHR) vs. Wistar-Kyoto rats (WKY) was evaluated on Preload recruitable stroke work (PRSW) (p=<0.01). At 10 to 11 months of age, spontaneously hypertensive rats exhibited higher preload recruitable stroke work compared to Wistar-Kyoto rats (174.5 vs 92.6 mm Hg; P<0.01).