What question did this study set out to answer?

The research aims to elucidate the role of DBI/ACBP in the pathogenesis of organ dysfunction during septic shock.

June 4, 2026Open Access

The autophagy-inhibitory tissue hormone DBI/ACBP contributes to the pathogenesis of multiple organ dysfunction syndrome in septic shock

Key Points

The research aims to elucidate the role of DBI/ACBP in the pathogenesis of organ dysfunction during septic shock.
Examined models of monomicrobial and polymicrobial sepsis to assess the effects of DBI/ACBP.
Analyzed its anti-autophagic, immunosuppressive, pro-inflammatory, and pro-senescent properties.
DBI/ACBP was identified as a pathogenic mediator of sepsis.
It was linked to increased inflammation and organ dysfunction.

Abstract

in models of monomicrobial and polymicrobial sepsis. Collectively, these findings identify DBI/ACBP as a pathogenic mediator of sepsis, consistent with its previously described anti-autophagic, immunosuppressive, pro-inflammatory and pro-senescent properties.

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Authors

Flavia Lambertucci

Centre National de la Recherche Scientifique

Maria Chiara Maiuri

Centre National de la Recherche Scientifique

Isabelle Martins

Inserm

Journals

Autophagy

Actions

Institutions

Inserm

Université Paris Cité

Sorbonne Université

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

The autophagy-inhibitory tissue hormone DBI/ACBP contributes to the pathogenesis of multiple organ dysfunction syndrome in septic shock

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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