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June 1, 2026AutophagyOpen Access

The autophagy-inhibitory tissue hormone DBI/ACBP contributes to the pathogenesis of multiple organ dysfunction syndrome in septic shock

Flavia Lambertucci Maria Chiara Maiuri Isabelle Martins Guido Kroemer

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Key Points

The research aims to elucidate the role of DBI/ACBP in the pathogenesis of organ dysfunction during septic shock.
Examined models of monomicrobial and polymicrobial sepsis to assess the effects of DBI/ACBP.
Analyzed its anti-autophagic, immunosuppressive, pro-inflammatory, and pro-senescent properties.
DBI/ACBP was identified as a pathogenic mediator of sepsis.
It was linked to increased inflammation and organ dysfunction.

Implication

Identifies DBI/ACBP as a mediator of organ dysfunction in sepsis, suggesting implications for treatment.

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Cite This Study

Lambertucci et al. (2026) studied this question.

synapsesocial.com/papers/6a2117dfd499ed480b170b47 https://doi.org/10.1080/15548627.2026.2673174

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